Dynamics of hypoxia activated pro-drugs (HAPs)
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Goals:
Use the biomechanical model to investigate dynamical changes in tumor microenvironment upon administration of drugs that are acivated in the regions of low oxygen (hypoxia).
Mathematical Model: A classical fluid-structure interaction technique called the Regularized Stokeslets methods was used to model flow of the interstitial fluid bewteen the tumor cells and convection-diffusion-reaction equations were used to model transport of both oxygen and hapoxia activated drug. Computational tools: The model is coded using the Matlab system, and all images and movies are made also using the Matlab system. Author: Kasia Rejniak: labpages.moffitt.org/rejniakk |
| Simulation movie: this simulation presents how hypoxia activated prodrug penetrate the tumor tissue, became activated in the hypoxic regions of the tissue and how the activated drug accumulates in the tumor cells and kill them. The movie shows three panels: top-left panel shows the distribution of oxygen within the tissue with yellow color representing high oxygen levels, and cyan the hypoxic regios; bottom-left panel shows the distribution of an in-active drug within the tissue with yellow color representing high drug concentration, and dark red representing low drug concentration; bottom-righ panel shows the distribution of an active drug within the tissue with yellow representing high drug concentration, and black dots representing dead cells. |