Goals:
Use the biomechanical model to investigate distribution of fluorescent biomarkers within a tumor tissue and their uptake by tumor cells.
Mathematical Model: A classical fluid-structure interaction technique called the Regularized Stokeslet mathod was used to model the interstitial fluid flow and transport of biomarker particles through the interstitial space between the cells. Computational tools: The model is coded using the Matlab system, and all images and movies are made also using the Matlab system. Author: Kasia Rejniak: labpages.moffitt.org/rejniakk |
Simulation movie: this simulation presents a patch of tissue with irregularly placed tumor cells, and particles of a fluorescent biomarker that move through the interstitial space by a combination of convective flow and diffusion. The cells can also take up the biomarker and accumulate it inside the cell cytoplasm. |