Computational Micro-Pharmacology Research Lab (CoMPhy Lab)

Our research focuses on mathematical modeling and computational simulations of tumor initiation, progression and treatment. Computational simulations give the unique opportunity for testing various scenarios of tumor emergence and growth, as well as different protocols of chemo-, radio-, immuno-, hormone- and combined therapies. In particular, we are interested in investigating the bio-mechanics of normal vs. tumor-like tissue morphogenesis, micro-fluids in drug delivery and bio-physics of tumor microenvironment using the IBCell model (immersed boundary model of a cell), the microPKPD (regularized Stokeslets method of micro-pharmacodynamics and pharmacokinetics), or the multiscale MultiCell-LF (multi-cell lattice-free), silicoDCIS, and Organoid3D models.

~~Multiple Research Positions Available~~

More information can be found here

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• in the media: This Week in Math Oncology features our LinG3D blog
• in the media: This Week in Math Oncology features our HAPs paper
• in the media: This Week in Math Oncology features our cell-ECM paper
• in the media: This Week in Math Oncology features our O2 fluctuation paper
• in the media: Advanced Science News featured our Hybrid Modeling review
• in the media: Shreya and Shannon about the HIP-IMO program (YouTube)
• in the media: MRI Spotlight Interview with Kasia Rejniak
• in the media: The Medicine Maker featured our Sci Reports paper
• in the media: Single-cell modeling & imaging for targeted drugs (Moffitt PR)
• in the media: Atlas of Science features our Virtual Clinical Trials paper
• in the media: Crunching cancer with digital drugs (p.28-30)
• in the media: Modeling the penetration of anti-cancer drugs (Moffitt PR)
• in the media: Miles for Moffitt Award and the pharmaco-mechanics project
• in the media: Global Medical Discovery features our CDK inhibitors paper

We are/were funded by:

NIH/NCI R01 grant with Damaghi lab

DoD Team Award grant with Pilon-Thomas and Poch lab

NIH/NCI R01 grant with Pilon-Thomas lab

NIH/NCI Physical Science-Oncology Projects (Vanderbilt-Moffitt U01)

Moffitt Team Science Award

Moffitt CIIRC Award

Bankhead Coley Bridge Award

NIH/NCI Integrative Cancer Biology Program (Vanderbilt-Moffitt ICBP)

NIH/NCI Physical Science-Oncology Center Program (Moffitt PSOC)

Miles for Moffitt Milestones Research Award

American Cancer Society-Institutional Research Grant